Correlation of fine needle aspiration biopsy and dynamic contrast-enhanced3D magnetic resonance imaging of the breast

OBJECTIVE: To correlate and assess the utility of dynamic contrast-enhanced three-dimensional gadolinium-enhanced magnetic resonance imaging (Gd-3DMRI ) and fine needle aspiration biopsy (FNAB) findings in patients with suspec ted breast disease. STUDY DESIGN: Beginning in 1993, all patients who underwent percutaneous FN AB of the breast and had concurrent Gd-3DMRI evaluation of the breast were selected for this study. Findings for FNAB and Gd-3DMRI were stratified int o two categories, positive and negative. Subsequent clinical management dec isions, which included surgical intervention and/or clinical follow-up, wer e recorded for ail patients. RESULTS: There were 69 FNABs in 59 patients with corresponding Gd-3DMRI eva luation. A positive result by both FNAB and Gd-3DMRI was found in 15 of 18 malignant cases. FNAB missed one case, and Gd-3DMRI missed two, and each of these was thought to be technical. Combining the methods yielded 100% sens itivity. False positive results on Gd-3DMRI (17 cases) were all confirmed t o be benign by FNAB and subsequent tissue evaluation. All 32 cases with com bined negative results by FNAB and Gd-3DMRI demonstrated a benign process, yielding a specificity of 100% (32/32). CONCLUSION: Our combined testing modalities showed a high degree of specifi city nr-rd goon sensitivity. FNAB used with dynamic contrast-enhanced Gd-3D MRI IRI can contribute valuable information for physicians treating patient s with suspected breast abnormalities.