IN-VITRO STUDY ON THE INTERACTION OF VALERIANA-OFFICINALIS L EXTRACTSAND THEIR AMINO-ACIDS ON GABA(A) RECEPTOR IN RAT-BRAIN

Authors
CAVADAS C ARAUJO I COTRIM MD AMARAL T CUNHA AP MACEDO T RIBEIRO CF
Citation
C. Cavadas et al., IN-VITRO STUDY ON THE INTERACTION OF VALERIANA-OFFICINALIS L EXTRACTSAND THEIR AMINO-ACIDS ON GABA(A) RECEPTOR IN RAT-BRAIN, Arzneimittel-Forschung, 45(7), 1995, pp. 753-755
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45
Issue
7
Year of publication
1995
Pages
753 - 755
Database
ISI
SICI code
0004-4172(1995)45:7<753:ISOTIO>2.0.ZU;2-K
Abstract
This work studied in vitro, the interaction of aqueous and hydroalcoho lic extracts of Valeriana officinalis L. and compounds that are presen t in the extracts (amino acids and valerenic acid) with the GABA(A) (g amma-aminobutyric acid) receptor, using the [H-3]muscimol binding tech nique to crude synaptic membranes from rat brain cortices. Both extrac ts displaced [H-3]muscimol bound and this effect is probably due only to their amino acid content, specially GABA. This fact explains the in vitro effect of valerian extracts on GABA(A) receptor but not their s edative effect.