DIFFERENT HEMODYNAMIC-EFFECTS OF CELIPROLOL AND ATENOLOL IN PATIENTS WITH MILD-TO-MODERATE HYPERTENSION

The hemodynamic effects of celiprolol (CAS 56980-93-9), a betablocker with beta(1) antagonist and beta(2) agonist properties, weve compared with those of atenolol (CAS 29122-68-7) in 12 patients with mild to mo derately severe hypertension (diastolic BP 95-110 mmHg). Celiprolol an d atenolol lend to a similar and significant reduction of systolic and diastolic blood pressure (p < 0.005). However, with celiprolol heart rate at rest was significantly less depressed then with atenolol (p = 0.004) and showed a distinctly less pronounced depression of heart rat e with exercise (p = 0.004). Cardiac output at rest was reduced by 19% ulcer atenolol, but was increased by 9% under celiprolol treatment in this respect, the two medications differed significantly (p = 0.03). The adaptation of heart rate and cardiac output to exercise was better with celipropol as compared to atenolol treatment. The difference bet ween arm arterial pressure and ankle occlusion pressure at rest was no t significantly influenced by atenolol, whereas ens celiprolol treatme nt increased this difference by a mean of up to 16 mmHg (p = 0.009). T his different effect on peripheral arterial circulation was even more pronounced after exercise Both celiprolol and atenolol increased blood cell flow velocity in the nailfold capillaries, but this increases wa s statistically only significant with celiprolol (p = 0.047). These re sults demonstrate that the hemodynamic effects of celiprolol were sign ificantly different from those of atenolol; celiprolol produces less b rady-cardia, increases cardiac output at rest and decreases peripheral arterial resistance. This lends to better adaptation of heart I ate a nd cardiac output to exercise, reflecting the cardiac beta(1) receptor inhibitory, and beta(2) receptor agonistic effects of celiprolol.