The role of membrane structure in activation of mitochondrial phospholipases - 2. Mechanism of crambin action on the activities of mitochondrial membrane phospholipases and microviscosity

The effects of crambin on the activities of phospholipases, lipid peroxidat ion and structure of mitochondrial membranes have been investigated. it has been shown that crambin inhibits lipid peroxidation and phospholipase acti vity induced by Ca2+ and freezing-thawing of mitochondria. These effects ar e based on the ability of crambin to cause changes in the mitochondrial mem brane structure, as has been shown by ESR studies.