Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate.

Authors
Srivastava, S Tewari, S Chauhan, PMS Puri, SK Bhaduri, AP Pandey, VC
Citation
S. Srivastava et al., Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate., BIOORG MED, 9(5), 1999, pp. 653-658
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
653 - 658
Database
ISI
SICI code
0960-894X(19990308)9:5<653:SOBATI>2.0.ZU;2-P
Abstract
Synthesis of a number of derivatives of bisquinolines (3-9) have been repor ted here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity. (C ) 1999 Elsevier Science Ltd. All rights reserved.