Synthesis of glucuronides of multidrug resistance reversing drug MS-209

Authors
Suzuki, T Mabuchi, K Fukazawa, N
Citation
T. Suzuki et al., Synthesis of glucuronides of multidrug resistance reversing drug MS-209, BIOORG MED, 9(5), 1999, pp. 659-662
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
659 - 662
Database
ISI
SICI code
0960-894X(19990308)9:5<659:SOGOMR>2.0.ZU;2-Q
Abstract
We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacet imidate gave two beta-isomers, which were each glucuronate of (R)- and (S)- MS-209. These spectrum data were identical with the metabolites. (C) 1999 E lsevier Science Ltd. All rights reserved.