Synthesis and activity of 2-(sulfonamido)methylcarbapenems: Discovery of anovel, anti-MRSA 1,8-naphthosultam pharmacophore

Authors
Wilkening, RR Ratcliffe, RW Wildonger, KJ Cama, LD Dykstra, KD DiNinno, FP Blizzard, TA Hammond, ML Heck, JV Dorso, KL St Rose, E Kohler, J Hammond, GG
Citation
Rr. Wilkening et al., Synthesis and activity of 2-(sulfonamido)methylcarbapenems: Discovery of anovel, anti-MRSA 1,8-naphthosultam pharmacophore, BIOORG MED, 9(5), 1999, pp. 673-678
Citations number
46
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
673 - 678
Database
ISI
SICI code
0960-894X(19990308)9:5<673:SAAO2D>2.0.ZU;2-P
Abstract
A series of 1 beta-methyl carbapenems substituted at the IL-position with l ipophilic, acyclic and cyclic (sulfonamido)methyl groups was prepared and e valuated for activity against resistant gram-positive bacteria. From these studies, the 1,8-naphthosultamyl group emerged as a novel, PBP2a-binding, a nti-MRSA pharmacophore worthy of further exploration. (C) 1999 Elsevier Sci ence Ltd. All rights reserved.