Antitumor agents 187: Synthesis and cytotoxicity o substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds

Authors
Yang, ZY Xia, Y Xia, P Tachibana, Y Bastow, KF Lee, KH
Citation
Zy. Yang et al., Antitumor agents 187: Synthesis and cytotoxicity o substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds, BIOORG MED, 9(5), 1999, pp. 713-716
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
713 - 716
Database
ISI
SICI code
0960-894X(19990308)9:5<713:AA1SAC>2.0.ZU;2-F
Abstract
Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and re lated compounds were synthesized and evaluated for their in vitro cytotoxic ity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI(50) values in the micromolar range. (C) 1999 Elsevier Science Ltd. All rights reserved.