Citation
Mk. Kundu et al., Antimalarial activity of 3-hydroxyalkyl-2-methylenepropionic acid derivatives, BIOORG MED, 9(5), 1999, pp. 731-736
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
731 - 736
Database
ISI
SICI code
0960-894X(19990308)9:5<731:AAO3AD>2.0.ZU;2-N
Abstract
Several Baylis-Hillman adducts and their derivatives were synthesized and e
valuated as targeted potential anti-malarials, The compounds 4, 7 and 9 wer
e found to have highest potency against P. falciparum in vitro. The in vivo
test result of compound 4 and 9 against P. berghei demonstrated activity a
t 80 mg/Kg dose level. (C) 1999 Elsevier Science Ltd. All rights reserved.