Studies towards the identification of potent, selective and bioavailable thrombin inhibitors

Authors
Ambler, J Baker, E Bentley, D Brown, L Butler, K Butler, P Farr, D Dunnet, K Le Grand, D Hayler, J Janus, D Jones, D Menear, K Mercer, M Smith, G Talbot, M Tweed, M
Citation
J. Ambler et al., Studies towards the identification of potent, selective and bioavailable thrombin inhibitors, BIOORG MED, 9(5), 1999, pp. 737-742
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
737 - 742
Database
ISI
SICI code
0960-894X(19990308)9:5<737:STTIOP>2.0.ZU;2-R
Abstract
The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. Th e utility of the approach is exemplified by the discovery of a potent, sele ctive and bioavailable thrombin inhibitor 62. (C) 1999 Elsevier Science Ltd . All rights reserved.