A new class of potent RAR antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids

Authors
Vuligonda, V Standeven, AM Escobar, M Chandraratna, RAS
Citation
V. Vuligonda et al., A new class of potent RAR antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids, BIOORG MED, 9(5), 1999, pp. 743-748
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
5
Year of publication
1999
Pages
743 - 748
Database
ISI
SICI code
0960-894X(19990308)9:5<743:ANCOPR>2.0.ZU;2-J
Abstract
The synthesis and biological activity of a novel series of tricyclic retino ic acid receptor antagonists are described. These compounds bind with high affinity to the RARs and are potent antagonists of retinoid function in in vitro and in vivo systems. (C) 1999 Elsevier Science Ltd. All rights reserv ed.