V. Vuligonda et al., A new class of potent RAR antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids, BIOORG MED, 9(5), 1999, pp. 743-748
The synthesis and biological activity of a novel series of tricyclic retino
ic acid receptor antagonists are described. These compounds bind with high
affinity to the RARs and are potent antagonists of retinoid function in in
vitro and in vivo systems. (C) 1999 Elsevier Science Ltd. All rights reserv
ed.