Three different autoimmune bullous diseases in one family: is there a common genetic base?

We report an unusual familial occurrence of autoimmune bullous diseases. Th ree members of a family suffered from three different autoimmune bullous di seases: pemphigus vulgaris (PV), linear IgA disease (LAD) and cicatricial p emphigoid (CP). The HLA type was determined in five family members: all wer e positive for HLA-DQ5/DR6, which is reported to be associated with suscept ibility to PV. The CP patient was DQ7(3) positive, which is in concordance with enhanced susceptibility to ocular CP and CP. The LAD patient was B8 an d DR3 negative but positive for HLA-A1. Our study supports the hypothesis t hat there is a genetically transmitted susceptibility to autoimmune bullous diseases but that additional factors seem necessary actually to develop a particular disease.