This study examines the characteristics of coronary lesions in which t
hrombus is found as assessed by angioscopy before percutaneous translu
minal coronary angioplasty in patients with various coronary syndromes
. Our findings demonstrate that the plaque underlying intracoronary th
rombus is usually yellow and/or disrupted, and support in vitro observ
ations that lipid-rich plaques are highly thrombogenic and that disrup
tion of these plaques is associated with in situ thrombosis.