Haemostatic and fibrinolytic responses to bone marrow transplantation

Thrombin and plasmin activation markers were serially measured in 80 patien ts undergoing bone marrow transplantation (BMT). There were prothrombotic a nd fibrinolytic responses observed during autograft and allograft BMTs. Thr ombin-antithrombin and prothrombin fragment F1 + 2 levels increased from da y -7 to -3 (P < 0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respect ively A rise in plasmin-antiplasmin levels occurred between days 4 and 14 ( P < 0.0004), from 393 ng/ml on day -7 to a peal; of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed.