COMPARISON OF THE IN-VITRO ACTIVITY OF FLUCONAZOLE AGAINST CANDIDA-ALBICANS AND DERMATOPHYTES

Citation
A. Wildfeuer et Hp. Seidl, COMPARISON OF THE IN-VITRO ACTIVITY OF FLUCONAZOLE AGAINST CANDIDA-ALBICANS AND DERMATOPHYTES, Arzneimittel-Forschung, 45(7), 1995, pp. 819-821
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
45
Issue
7
Year of publication
1995
Pages
819 - 821
Database
ISI
SICI code
0004-4172(1995)45:7<819:COTIAO>2.0.ZU;2-5
Abstract
Fluconazole (CAS 86386-73-4, Diflucan(R), Fungata(R)) is an antimycoti c agent of established value in the treatment of systemic infections w ith yeasts; move recently this drug has been used in the oral treatmen t of dermatomycoses. The in vitro activity of fluconazole against 51 s trains of C. albicans and 207 isolates of four different species of de rmatophytes was therefore measured and the results collated The mean m inimal inhibitory concentrations (MIC) show that in vitro fluconazole is a significantly stronger inhibitor of the proliferation of C. albic ans (0.34 mu g/ml) than of the dermatophytes T. rubrum (6.4 mu g/ml), T. mentagrophytes (23.9 mu g/ml), M. canis (18.3 mu g/ml) and E. flocc osum (3.5 mu g/ml). On the other hand the distribution of the MIC valu es shows that the sensitivity to fluconazole within a single species i s also very variable. It is evident that the concentrations of flucona zole reached particularly in the stratum corneum of the skin after ora l therapy are adequate to inhibit the growth of the yeasts and of the dermatophytes examined.