A. Wildfeuer et Hp. Seidl, COMPARISON OF THE IN-VITRO ACTIVITY OF FLUCONAZOLE AGAINST CANDIDA-ALBICANS AND DERMATOPHYTES, Arzneimittel-Forschung, 45(7), 1995, pp. 819-821
Fluconazole (CAS 86386-73-4, Diflucan(R), Fungata(R)) is an antimycoti
c agent of established value in the treatment of systemic infections w
ith yeasts; move recently this drug has been used in the oral treatmen
t of dermatomycoses. The in vitro activity of fluconazole against 51 s
trains of C. albicans and 207 isolates of four different species of de
rmatophytes was therefore measured and the results collated The mean m
inimal inhibitory concentrations (MIC) show that in vitro fluconazole
is a significantly stronger inhibitor of the proliferation of C. albic
ans (0.34 mu g/ml) than of the dermatophytes T. rubrum (6.4 mu g/ml),
T. mentagrophytes (23.9 mu g/ml), M. canis (18.3 mu g/ml) and E. flocc
osum (3.5 mu g/ml). On the other hand the distribution of the MIC valu
es shows that the sensitivity to fluconazole within a single species i
s also very variable. It is evident that the concentrations of flucona
zole reached particularly in the stratum corneum of the skin after ora
l therapy are adequate to inhibit the growth of the yeasts and of the
dermatophytes examined.