Synthesis and evaluation of the cholic acid derivatives with multitrifluoroacetylbenzoyl (TFAB) groups as carbonate ionophores

Authors
Pyun, HJ Chu, JH Yoon, W Jun, YM Kim, DJ
Citation
Hj. Pyun et al., Synthesis and evaluation of the cholic acid derivatives with multitrifluoroacetylbenzoyl (TFAB) groups as carbonate ionophores, B KOR CHEM, 20(2), 1999, pp. 179-186
Citations number
35
Categorie Soggetti
Chemistry
Journal title
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN journal
02532964 → ACNP
Volume
20
Issue
2
Year of publication
1999
Pages
179 - 186
Database
ISI
SICI code
0253-2964(19990220)20:2<179:SAEOTC>2.0.ZU;2-L
Abstract
Several cholic acid derivatives containing 1-3 trifluoroacetylbenzoyl (TFAB ) moieties were synthesized using selective acetylations, hydrolysis and/or oxidation of cholic acid derivatives and tested as receptors for a carbona te ion through solvent extraction method. The compounds having two and thre e TFAB moieties exhibited enhanced binding affinities toward a carbonate io n in comparison with those with one TFAB group and the extent of complex fo rmation also depended on the position of TFAB group attached.