High performance liquid chromatography method for the determination of meropenem in human plasma

This paper describes an HPLC method for the determination of meropenem in h uman plasma. The method uses solid phase extraction (SPE) of the samples an d has good sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.02 mu g mL(-1). Calibration curves were linear over a large dynamic range, namely within 0.02-50 mu g mL(-1). The method was a pplied to the determination of meropenem levels in patients receiving merop enem, as a single dose or at steady state.