D. Farin et al., High performance liquid chromatography method for the determination of meropenem in human plasma, CHROMATOGR, 49(5-6), 1999, pp. 253-255
This paper describes an HPLC method for the determination of meropenem in h
uman plasma. The method uses solid phase extraction (SPE) of the samples an
d has good sensitivity, precision and accuracy. The limit of quantification
in plasma samples is 0.02 mu g mL(-1). Calibration curves were linear over
a large dynamic range, namely within 0.02-50 mu g mL(-1). The method was a
pplied to the determination of meropenem levels in patients receiving merop
enem, as a single dose or at steady state.