Acetylation and formylation of 3-ferrocenylpyrroles

Acetylations of 3-ferrocenyl-1-methylpyrrole as well as 3-cyano-4-ferroceny lpyrrole and 3-cyano-4-ferrocenyl-1-methylpyrrole were performed. The cours e of the acylation is highly dependent on the acylation agent, that is acet yl chloride/aluminum chloride (method A), trifluoroacetic anhydride-acetic acid mixture (method B) or acetic anhydride/Sc(OTf)(3) (method C). Method A gives the acetylation on ferrocene moiety, method B affords the trifluoroa cetylation on pyrrole moiety and method C affords pyrrole moiety acetylatio n. Vielsmeier-Haack formylation gives the products of substitution on pyrro le moiety.