Acetylations of 3-ferrocenyl-1-methylpyrrole as well as 3-cyano-4-ferroceny
lpyrrole and 3-cyano-4-ferrocenyl-1-methylpyrrole were performed. The cours
e of the acylation is highly dependent on the acylation agent, that is acet
yl chloride/aluminum chloride (method A), trifluoroacetic anhydride-acetic
acid mixture (method B) or acetic anhydride/Sc(OTf)(3) (method C). Method A
gives the acetylation on ferrocene moiety, method B affords the trifluoroa
cetylation on pyrrole moiety and method C affords pyrrole moiety acetylatio
n. Vielsmeier-Haack formylation gives the products of substitution on pyrro
le moiety.