A short tutorial and a rationale for Object-Oriented Biomedical (Continuous
) System Modelling (OOBSM) are given. The paper investigates and defines wh
at is needed in order to make the work with complex bio-medical and pathoph
ysiological models easier, less error prone and conceptually clearer than i
s possible by using the existing modelling techniques. It also contains a s
pecification of what is required in order to make such models and correspon
ding knowledge communicable among different research groups and in order to
use such models as components in even more complex models. The work shows
that hitherto available continuous system modelling languages and tools are
less suitable for the construction of complex, interdisciplinary, multilev
el, hierarchical models and model components and that those modelling langu
ages do not allow for easy exchange and communication of the model knowledg
e between different research groups and sites. It concludes that object-ori
ented and distributed objects methodologies are both feasible and suitable
for such modelling. (C) 1999 Elsevier Science Ireland Ltd. All rights reser
ved.