Js. Gammie et Sm. Pham, Simultaneous donor bone marrow and cardiac transplantation: Can tolerance be induced with the development of chimerism?, CURR OPIN C, 14(2), 1999, pp. 126-132
Mixed bone marrow chimerism (mixed chimerism) is defined by the coexistence
of two genetically different bone marrow stem cells in an individual. The
chimeric immune system recognizes donor antigen as self, yet is capable of
mounting a normal response to third-party antigens. In animal models, mixed
chimerism confers donor-specific tolerance for solid-organ and cellular gr
afts: tissue from the bone marrow donor is permanently accepted by mixed ch
imeras in the absence of conventional immunosuppressive agents. Clinical ap
plication of mixed chimerism to induce transplantation tolerance requires n
ovel approaches to safely and reliably achieve engraftment of donor bone ma
rrow in transplant recipients. Recent advances offer potential solutions to
these obstacles and suggest that the application of mixed chimerism to ind
uce tolerance to transplanted organs may soon be a clinical reality.