Ta. Korolenko et al., Study of the antitumor effect of Ukrain: The role of macrophage secretion of alpha-1-proteinase inhibitor, DRUG EXP CL, 24(5-6), 1998, pp. 271-276
The positive antitumor effect of Ukrain was shown following i.m. injection
of a mixture of this drug with Krebs-2 carcinoma cells to CBA mice. The pro
tective effect was suggested to be a result of the influx of macrophages in
to the site of Ukrain injection. In contrast, contralateral administration
of Ukrain had a negative effect, confirming our hypothesis that Ukrain attr
acts cytolytic macrophages. In the murine HA-1 hepatoma model treated by si
ngle or repeated Ukrain injections, a moderate positive effect of Ukrain wa
s related to increased macrophage alpha-1-proteinase inhibitor (PI) secreti
on. The role of tumor cells and macrophages in the secretion of PI (the mai
n inhibitor of serine proteinases) during tumor development is discussed.