Six-week treatment with Ukrain in rabbits. Part I: Morphological parameters

This study was performed to evaluate the effect of 6-week treatment with Uk rain in doses of 0.3, 1.5 and 3.0 mg/kg i.v. on the morphological and bioch emical parameters of peripheral blood and morphology of body organs in rabb its. Ukrain application did not change the body organs and total body weigh t The drug did not affect biochemical parameters of peripheral blood, excep t for a minor reduction in the fetal plasma level and increases in serum ur ic acid and urea indicating enhanced catabolism of proteins. The peripheral erythrocyte and leukocyte counts were not altered, whereas the percentages of lymphocytes, monocytes, and eozynophils were increased after higher dos es of Ukrain. An increase in rod neutrophils and a decrease in the percenta ge of segmented neutrophils were also noted. These observations indicate a lack of organ toxicity following long-term treatment with Ukrain.