Six-week treatment with Ukrain in rabbits. Part III: Serum levels of thyroid hormones

The influence of 6-week treatment with Ukrain at doses of 0.3 1.5 and 3.0 m g/kg i.v. on serum levels of thyroid hormones, i.e., thyroxine and triiodot hyronine, was studied in rabbits of both sexes. Ukrain affected the serum l evels of both hormones in males. An increase in the thyroxine level was fou nd after Ukrain used at a dose of 1.5 and 3.0 mg/kg i.v., whereas increased triiodothyronine was noted when Ukrain was given at all studied doses. In females the thyroxine level was not altered by Ukrain administration, where as the triiodothyronine concentration was increased following Ukrain at 0.3 , 1.5 and 3.0 mg/kg i.v. If is probable that the altered thyroid hormone le vels as a result of Ukrain application may contribute to the drug's potent immunomodulatory action.