Preliminary pharmacokinetic studies of Ukrain in rats

Ukrain (thiophosphoric acid derivative of Chelidonium majus L alkaloids) wa s administered to rats i.p. at a dose of 28 mg/kg (equivalent to 0.1 LD50) A high performance liquid chromatography (HPLC) method for rapid determinat ion of Ukrain in plasma has been described. If was found that Ukrain rapidl y penetrated into the plasma of the rats and the elimination of the drug fr om the plasma was slower: The results obtained were as follows: absorption rate constant k(a) = 0.0432 [min(-1)]; elimination rate constant K = 0.0113 [min(-1)]; drug half-life t(1/2) = 61.32 min; actual concentration of Ukra in in the plasma C = 33 e (-0.0113t) - 39 e (-0.0432t) [mu g/ml]; and delay in drug absorption T-0 = 5.23 min.