Citation
E. Jagiello-wojtowicz et al., Interaction between Ukrain and naltrexone in the writhing syndrome test inmice, DRUG EXP CL, 24(5-6), 1998, pp. 327-330
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
ISSN journal
03786501
→ ACNP
Volume
24
Issue
5-6
Year of publication
1998
Pages
327 - 330
Database
ISI
SICI code
0378-6501(1998)24:5-6<327:IBUANI>2.0.ZU;2-E
Abstract
The interaction between Ukrain and Naltrexone, a nonselective opioid recept
or antagonist, was studied in the 'writhing syndrome' test in mice. Naltrex
one (1 mg/kg s.c.) was administered i.p. 30 min before Ukrain (2.375, 4.75,
9.5 and 19 mg/kg). In addition, the antinociceptive properties of Ukrain a
nd Naltrexone in 10-day treatment in mice were studied. The results show th
at the antinociceptive effect of both single dose and prolonged administrat
ion of Ukrain is completely antagonized by Naltrexone.