Synthesis of gamma-amino- and delta-amino-functionalised ethers, amines, or silanes by hydroaminomethylation of heterofunctionalised allylic compounds

Heterofunctionalised allylic ethers 1, silanes 5, and amines 9 are hydrofor mylated in the presence of primary or secondary amines 2 to form the corres ponding gamma-amino- and delta-amino- functionalised compounds. The rhodium (I)-catalysed reaction sequence proceeds by aldehyde formation and subseque nt reductive amination to generate thecorresponding functionalised secondar y or tertiary amines. This selective one-pot hydroaminomethylation procedur e establishes access to gamma-amino- and delta-amino-functionalised ethers, amines or silanes with potential biological activity.