Tj. Sajdyk et al., Amygdalar neuropeptide Y Y-1 receptors mediate the anxiolytic-like actionsof neuropeptide Y in the social interaction test, EUR J PHARM, 368(2-3), 1999, pp. 143-147
The effects of intra-amygdalar neuropeptide Y infusions were assessed in ra
ts using the social interaction test. Neuropeptide Y administered into the
central nucleus of the amygdala did not alter behavior, while injections in
to the basolateral nucleus of the amygdala produced an increased social int
eraction time. Furthermore, the anxiolytic-like effect was antagonized by c
o-administration of the potent neuropeptide Y Y-1 receptor antagonist ((R)-
N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphenylacetyl)-arginin
amide trifluoroacetate) 3304, but not with the inactive enantiomer (( R)-N-
[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphenylacetyl)-argininam
ide trifluoroacetate) 3457. Therefore, neuropeptide Y produces an anxiolyti
c-like effect in the social interaction test through neuropetide Y Y-1 rece
ptors located in the basolateral amygdala. (C) 1999 Elsevier Science B.V. A
ll rights reserved.