Objective: To report on the experience obtained in the treatment of a serie
s of 150 cases of ureteral stone disease by means of the holmium:yttrium-al
uminum-garnet (Ho:YAG) laser. Methods: One hundred and fifty consecutive ca
ses treated by means of Ho:YAG laser ureterolithotripsy have been reviewed
in order to assess the results. In 81 cases the stones were located in the
lower third, in 47 in the medium third, and in 22 cases in the upper third
of the ureter. The laser was set at a power of 8-10 W and at a frequency of
between 6 and 10 Hz. Thin ureteroscopes were selected, such as the 7-Fr Ga
utier or the new ultrathin 4.8-Fr Wolf instrument. In some cases other uret
eroscopes were chosen. Results: Lasertripsy was effective in every kind of
stone, allowing fragmentation into portions measuring at most 4 mm (largest
diameter) or disintegration. The clearance rate of the stones was 92.6% du
ring the 30-day follow-up period. Calcium dihydrate stones were of course m
ore easily broken than monohydrate ones, No damage to the ureter was observ
ed following the vaporization which is produced by this kind of laser, sinc
e particular attention was paid to avoid any contact between the laser beam
and the ureteral mucosa. In some instances ureteroscopic maneuvering provo
ked some slight lacerations. In a few cases accidental contact of the laser
beam with the ureteral mucosa produced extremely small coagulations of no
immediate or postoperative relevance. Conclusions: The Ho:YAG laser constit
utes an effective instrument for the fragmentation of any kind of ureteral
stone; it allows the use of thin or ultrathin instruments and, if manipulat
ed with care, does not damage the ureteral mucosa or the ureteral wall.