Evidence for an ancient chromosomal duplication in Arabidopsis thaliana bysequencing and analyzing a 400-kb contig at the APETALA2 locus on chromosome 4

Authors
Terryn, N Heijnen, L De Keyser, A Van Asseldonck, M De Clercq, R Verbakel, H Gielen, J Zabeau, M Villarroel, R Jesse, T Neyt, P Hogers, R Van den Daele, H Ardiles, W Schueller, C Mayer, K Dehais, P Rombauts, S Van Montagu, M Rouze, P Vos, P
Citation
N. Terryn et al., Evidence for an ancient chromosomal duplication in Arabidopsis thaliana bysequencing and analyzing a 400-kb contig at the APETALA2 locus on chromosome 4, FEBS LETTER, 445(2-3), 1999, pp. 237-245
Citations number
24
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
445
Issue
2-3
Year of publication
1999
Pages
237 - 245
Database
ISI
SICI code
0014-5793(19990226)445:2-3<237:EFAACD>2.0.ZU;2-M
Abstract
As part of the European Scientists Sequencing Arabidopsis program, a contig uous region (396 607 bp) located on chromosome 4 around the APETALA2 gene w as sequenced. Analysis of the sequence and comparison to public databases p redicts 103 genes in this area, which represents a gene density of one gene per 3.85 kb, Almost half of the genes show no significant homology to know n database entries. In addition, the first 45 kb of the contig, which cover s 11 genes, is similar to a region on chromosome 2, as far as coding sequen ces are concerned. This observation indicates that ancient duplications of large pieces of DNA have occurred in Arabidopsis. (C) 1999 Federation of Eu ropean Biochemical Societies.