Superior cervical ganglionectomy-induced lowering of intraocular pressure in rabbits: role of prostaglandins and neuropeptide Y

At 22-24 h after unilateral ganglionectomy (SX), intraocular pressure (IOP) was significantly (p < 0.001) reduced in SX eyes compared either with the contralateral, normally innervated eyes or with baseline measurements. SX r aised prostaglandin E-2 (PGE(2)), PGF(2 alpha), and neuropeptide Y (NPY) co ncentrations in the aqueous humor but reduced these levels in the iris-cili ary body. At 22-24 h after bilateral SX, flurbiprofen (0.03%) significantly (p < 0.001) inhibited the reduction of IOP and the elevation of PGE(2) and PGF(2 alpha) levels in the aqueous humor. We conclude that PGs mediate the reduction of IOP at 22-24 h after SX. (C) 1999 Elsevier Science Inc. All r ights reserved.