Two B-1 and B-2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts

Authors
Cassano, G Susca, F Lippe, C Guanti, G
Citation
G. Cassano et al., Two B-1 and B-2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts, GEN PHARM, 32(2), 1999, pp. 239-244
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
GENERAL PHARMACOLOGY
ISSN journal
03063623 → ACNP
Volume
32
Issue
2
Year of publication
1999
Pages
239 - 244
Database
ISI
SICI code
0306-3623(199902)32:2<239:TBABBR>2.0.ZU;2-A
Abstract
The elevation of intracellular [Ca2+] induced by bradykinin (Bk) was monito red with fura-2 fluorescence in human skin fibroblasts. Neither [des-Arg(10 )][Leu(9)]kallidin nor D-Arg[Hyp(3),Thi(5),D-TiC7,OiC(8)]bradykinin (HOE140 ) inhibited the Ca2+ response stimulated by Bk. Moreover, each behaved as a partial agonist causing the elevation of intracellular[Ca2+]. (C) 1999 Els evier Science Inc. All rights reserved.