Citation
E. Zavadova et al., The role of macrophages in antitumor defense of patients with ovarian cancer, HEMAT ONCOL, 13(1), 1999, pp. 135
Citations number
48
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
ISSN journal
08898588
→ ACNP
Volume
13
Issue
1
Year of publication
1999
Database
ISI
SICI code
0889-8588(199902)13:1<135:TROMIA>2.0.ZU;2-C
Abstract
Macrophages have diverse effects on tumor biology, including neovasculariza
tion, growth rate, and stroma formation. Tumor-associated macrophages (TAMs
) represent a major subpopulation of the mononuclear leukocytes present in
malignant ascites of ovarian cancer patients. TAMs appear to participate in
the immunologic antitumor defense mechanism through cytotoxic activities,
such as direct cellular cytotoxicity and the release of cytokines, and may
represent key targets for a variety of therapeutic interventions.