M. Kodama et al., SCALE-UP OF LIQUID-CHROMATOGRAPHY FOR INDUSTRIAL-PRODUCTION OF PARENTERAL ANTIBIOTIC E1077, Journal of chromatography, 707(2), 1995, pp. 117-129
Citations number
14
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Purification is a key process for the commercialization of new chemica
l compounds. This is especially the case of pharmaceutical compounds,
which require high quality. Optimization of the purification process i
s a primary concern. An industrial-scale process was developed for syn
thesizing a new cephalosporin, inopropenyl-7-fluoromethoxyiminothiadia
zolylcephem (E-1077). Column chromatography was applied to purify this
product. Optimum conditions for production were determined on the bas
is of analytical-scale studies. The process was then scaled up to the
pilot production of samples. In order to achieve successful scale-up o
f industrial chromatography, it is necessary to consider the chemical
nature of the crude compound and optimization of each step in the tota
l production process.