Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25

Authors
Delgado, MA Solbiati, JO Chiuchiolo, MJ Farias, RN Salomon, RA
Citation
Ma. Delgado et al., Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25, J BACT, 181(6), 1999, pp. 1968-1970
Citations number
24
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
181
Issue
6
Year of publication
1999
Pages
1968 - 1970
Database
ISI
SICI code
0021-9193(199903)181:6<1968:ECOMPT>2.0.ZU;2-A
Abstract
A Tn5 insertion in tolC eliminated microcin J25 production. The mutation ha d little effect on the expression of the microcin structural gene and presu mably acted by blocking microcin secretion. The tolC mutants carrying multi ple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD im munity protein, an ABC exporter.