Serendipitous synthesis of N-tetrachlorophthaloyl-dehydroalanine methyl ester, a Michael acceptor which is a potential precursor of gamma-carboxyglutamic acid

Authors
Caillard, M Emm, A Jones, A Matthews, T Williams, JM
Citation
M. Caillard et al., Serendipitous synthesis of N-tetrachlorophthaloyl-dehydroalanine methyl ester, a Michael acceptor which is a potential precursor of gamma-carboxyglutamic acid, J CHEM R-S, (12), 1998, pp. 806-807
Citations number
4
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
12
Year of publication
1998
Pages
806 - 807
Database
ISI
SICI code
0308-2342(199812):12<806:SSONME>2.0.ZU;2-Q
Abstract
An attempt to synthesise a new protected serine derivative led to the isola tion of N-tetrachlorophthaloyldehydroalanine methyl ester, which underwent Michael addition of dialkyl malonates to form gamma-carboxyglutamic acid de rivatives.