Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium

Citation
Hs. Taylor et al., Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium, J CLIN END, 84(3), 1999, pp. 1129-1135
Citations number
42
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
ISSN journal
0021972X → ACNP
Volume
84
Issue
3
Year of publication
1999
Pages
1129 - 1135
Database
ISI
SICI code
0021-972X(199903)84:3<1129:SSMHEI>2.0.ZU;2-H
Abstract
Under the influence of sex steroids, human endometrium undergoes sequential development in preparation for implantation. Hoxa11 is essential for impla ntation in the mouse. Here we describe a potential role for HOXA11 in human endometrial development and implantation. Northern analysis demonstrates t hat HOXA11 is expressed in a menstrual cycle phase-dependent fashion in adu lt human endometrium. HOXA11 messenger RNA levels dramatically increase at the time of implantation and remain increased in pregnancy. In vitro, HOXA1 1 expression is increased in response to estrogen or progesterone. There is a dose-responsive increase over the physiologic range of progesterone conc entration. Pretreatment with Cyclohexamide does not decrease the response t o estrogen. Steroids are novel regulators HOX gene expression. The spatial and temporal pattern of HOXA11 expression in the human endometrium suggests a role in endometrial development, implantation, and maintenance of pregna ncy.