Correction for partial volume effects in regional blood flow measurements adjacent to hematomas in humans with intracerebral hemorrhage: Implementation and validation
To. Videen et al., Correction for partial volume effects in regional blood flow measurements adjacent to hematomas in humans with intracerebral hemorrhage: Implementation and validation, J COMPUT AS, 23(2), 1999, pp. 248-256
Citations number
34
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Purpose: Reduced blood flow measured with PET and SPECT has been reported i
n brain surrounding intracerebral hemorrhage (ICH). These studies have not
corrected for partial volume effects from adjacent hematomas or ventricles.
We have implemented a method to correct for these effects at brain boundar
ies (but not at internal gray/white matter boundaries), tested it with a br
ain phantom, and applied it to patients.
Method: Using PET and X-ray CT images of a Hoffman brain phantom containing
artificial hematomas, we segmented CT images to binary images representing
brain tissue and convolved these to the 3D resolution of the PET. PET imag
es were then scaled by this net tissue contribution. Corrected images were
compared with other images of the same phantom without hematomas. The same
correction was then applied to human images.
Results: Uncorrected phantom images had artifactual reductions surrounding
hematomas that were eliminated by the correction. Corrected images,of patie
nts with acute ICH had areas of reduced flow in white and deep gray matter,
whereas overlying cortical flow was preserved.
Conclusion: We have validated a method to correct for artifactual reduction
s in blood flow measurements at brain boundaries. Using this method, we obs
erve areas with reduced flow near acute hematomas.