HEMOSTATIC CHANGES IN PATIENTS WITH DEEP-VEIN THROMBOSIS

Thrombomodulin (TM), beta-thromboglobulin (beta-TG), D-dimer (DD), tis sue-type plasminogen-activator (t-PA), plasminogen activator-inhibitor (PAI-1) and quantitative determination of functional protein S (PS) w ere measured using ELISA procedures in the plasma of 16 untreated pati ents with newly-diagnosed deep vein thrombosis in the leg and in 10 he althy volunteers, No significant difference in plasma TM, t-PA and PS levels was observed among the controls and patients with deep vein thr ombosis, These patients, on the other hand, showed plasma DD, beta-TG and PAI-1 levels significantly higher than the control subjects, These data show that in patients with deep vein thrombosis a hypercoagulabl e state is a common occurrence.