IN-VITRO ANTIFUNGAL ACTIVITY OF THE NEW TRIAZOLE D0-870 AGAINST PENICILLIUM-MARNEFFEI COMPARED WITH THAT OF AMPHOTERICIN-B, FLUCONAZOLE, ITRACONAZOLE, MICONAZOLE AND FLUCYTOSINE

Authors
BOONLONG J MEKHA N POONWAN N KUSUM M MIKAMI Y YAZAWA K KONYAMA K
Citation
J. Boonlong et al., IN-VITRO ANTIFUNGAL ACTIVITY OF THE NEW TRIAZOLE D0-870 AGAINST PENICILLIUM-MARNEFFEI COMPARED WITH THAT OF AMPHOTERICIN-B, FLUCONAZOLE, ITRACONAZOLE, MICONAZOLE AND FLUCYTOSINE, Mycoses, 39(11-12), 1996, pp. 453-456
Citations number
18
Categorie Soggetti
Dermatology & Venereal Diseases",Mycology
Journal title
Mycoses → ACNP
ISSN journal
09337407
Volume
39
Issue
11-12
Year of publication
1996
Pages
453 - 456
Database
ISI
SICI code
0933-7407(1996)39:11-12<453:IAAOTN>2.0.ZU;2-X
Abstract
The in vitro activity of D0870, a new triazole, was compared with that of fluconazole, itraconazole, miconazole, amphotericin B and flucytos ine against recent clinical isolates of Penicillium marneffei in Thail and. The minimum inhibitory concentrations (MIC) values were determine d by a microbroth dilution method using morpholinopropanesulphonic aci d (MOPS)-buffered RPMI-1640 and brain heart infusion (BHI) medium. Yea st nitrogen base (YNB) medium with glucose was also used for the assay of flucytosine. D0870 was less active against P. marneffei than itrac onazole, but its activity was similar to that of miconazole, superior to that of amphotericin B and markedly superior to that of fluconazole and flucytosine. Much lower MIC values of D0870 were observed with BH I medium.