IN-VITRO ANTIFUNGAL ACTIVITY OF THE NEW TRIAZOLE D0-870 AGAINST PENICILLIUM-MARNEFFEI COMPARED WITH THAT OF AMPHOTERICIN-B, FLUCONAZOLE, ITRACONAZOLE, MICONAZOLE AND FLUCYTOSINE
J. Boonlong et al., IN-VITRO ANTIFUNGAL ACTIVITY OF THE NEW TRIAZOLE D0-870 AGAINST PENICILLIUM-MARNEFFEI COMPARED WITH THAT OF AMPHOTERICIN-B, FLUCONAZOLE, ITRACONAZOLE, MICONAZOLE AND FLUCYTOSINE, Mycoses, 39(11-12), 1996, pp. 453-456
The in vitro activity of D0870, a new triazole, was compared with that
of fluconazole, itraconazole, miconazole, amphotericin B and flucytos
ine against recent clinical isolates of Penicillium marneffei in Thail
and. The minimum inhibitory concentrations (MIC) values were determine
d by a microbroth dilution method using morpholinopropanesulphonic aci
d (MOPS)-buffered RPMI-1640 and brain heart infusion (BHI) medium. Yea
st nitrogen base (YNB) medium with glucose was also used for the assay
of flucytosine. D0870 was less active against P. marneffei than itrac
onazole, but its activity was similar to that of miconazole, superior
to that of amphotericin B and markedly superior to that of fluconazole
and flucytosine. Much lower MIC values of D0870 were observed with BH
I medium.