Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia

Authors
Voulgaropoulou, F Tan, B Soares, M Hahn, B Ratner, L
Citation
F. Voulgaropoulou et al., Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia, J VIROLOGY, 73(4), 1999, pp. 3497-3504
Citations number
82
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
4
Year of publication
1999
Pages
3497 - 3504
Database
ISI
SICI code
0022-538X(199904)73:4<3497:DHIVSI>2.0.ZU;2-V
Abstract
We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytope nic patients contained distinct amino acids in the V3 loop and infected T-c ell lines, implicating this virus in the development of thrombocytopenia.