Progressive supranuclear palsy

Richardson observed an unusual clinical syndrome in the 1950s, which he lat er designated progressive supranuclear palsy (PSP). Over the past 25 years, although knowledge of this disorder has gradually improved, its cause is s till unknown, pathogenesis is unclear, and there is still no definitive tre atment for this disorder. This article reviews the epidemiology, clinical f eatures, diagnostic criteria, neuropathology, neuroimaging, and treatment o f PSP.