The use of fluconazole as a local irrigant for nephrostomy tubes

Objectives: Few data exist concerning the combined use of fluconazole syste mically and as an irrigant for nephrostomy tubes in a patient with renal ca ndidiasis. The patient described here presented with renal fungal balls obs tructing the drainage of urine from her nephrostomy tubes. Methods: Twelve months after chemoradiation for a stage IIB squamous cell carcinoma of the uterine cervix, a 35-year-old woman presented with renal obstruction necess itating insertion of ureteral stents. After 6 months of chemotherapy, the p atient developed uremia. After nephrostomy tubes were placed, renal candidi asis was noted, and fluconazole was begun systemically. When the renal cand idiasis failed to clear, nephrostomy tube irrigations were begun. Results: Fourteen days of therapy with fluconazole resulted in the resolution of the uremia. The patient died 6 months later with her nephrostomy tubes in situ and without evidence of candidiasis in her urinary tract. Conclusions: The patient described was successfully treated without having to remove her ne phrostomy tubes. Two other authors have reported the successful use of fluc onazole irrigation to treat candidiasis in nephrostomy tubes that was unres ponsive to systemic fluconazole. Before the appearance of these reports, th e best results were obtained with removal of the catheter in renal candidia sis.