Sarcoidosis with selective involvement of a second liver allograft: Reportof a case and review of the literature

A case of sarcoidosis recurrent in a patient's second liver allograft is de scribed. There was no granulomatous disease seen in the patient's first liv er allograft. After the second orthotopic liver transplantation (OLT), the patient was successfully treated for acute rejection, aspergillus infection , and cytomegalovirus viremia. Approximately 2 months after the second OLT, the patient was treated with long-term interferon-cu for recurrent hepatit is C. Five years after the operation, he experienced liver failure secondar y to recurrent hepatitis and underwent a third OLT. This is only the second reported case of sarcoidosis recurrent in the liver parenchyma of a transp lanted organ and the first in which interferon-cr might have played a role.