GASTRIC-MUCOSAL PH AND OXYGEN DELIVERY AND OXYGEN-CONSUMPTION INDEXESIN THE ASSESSMENT OF ADEQUACY OF RESUSCITATION AFTER TRAUMA - A PROSPECTIVE, RANDOMIZED STUDY

Objective: To compare gastric mucosal pH (pHi) and global oxygen varia bles [Oxygen Delivery Index (DO2I) and Oxygen Consumption Index (VO2I) ] as indicators of adequacy of resuscitation after major trauma. Metho ds: Twenty-seven patients were prospectively randomized into two group s: group 1 (n = 11), normalization and maintenance of pi-Ii at or abov e 7.30; and group 2 (n = 16), maintaining a DO2I of 600 and a VO2I of >150. The groups had statistically similar injury severity scores, lac tate, and base deficit. Results: The goals of therapy were achieved wi thin 24 hours of admission in 10 of the 11 patients in group 1 and in 15 of the 16 patients in group 2. One patient (9.1%) in group 1 died. This patient had transient stabilization of pHi to 7.3 and subsequentl y had persistent mucosal acidosis, Of the 10 patients with pHi > 7.3 a t 24 hours 9 survived. In group 2, 5 (31.3%) died. Four of the 5 nonsu rvivors had achieved DO2I and VO2I goals, but had pHi < 7.3 at 24 hour s. A comparison of time taken for optimization of DO2I, VO2I, lactate, base excess, and pHi showed pHi and lactate as the variables differen t in survivors and nonsurvivors, Six: of the 8 patients who developed multiple organ dysfunction syndrome had pHi < 7.3 at 24 hours. Persist ently low pHi was the first sign of bacteremia (3 patients), small bow el gangrene or pregangrene (2 patients), intestinal anastomotic leak ( 2 patients), intra-abdominal hypertension (4 patients), and intra-abdo minal abscess (5 patients), It was the first finding in all the nonsur vivors at least 72 hours before death. Conclusions: pHi may be an impo rtant marker to assess the adequacy of resuscitation. pHi monitoring m ay provide early warning for systemic complications in the postresusci tation period.