Background: Peritonitis is a common complication in patients with end-stage
renal disease treated by continuous ambulatory peritoneal dialysis (CAPD).
Empirical treatment is based on the organisms that are most frequently iso
lated and their susceptibilities.
Objective:To analyze and then compare peritoneal fluid culture results from
adult and pediatric patients on CAPD, with respect to micro-organisms and
antimicrobial susceptibilities.
Design:Three-year retrospective review of peritoneal fluid cultures from ad
ults and children on CAPD.
Results:We isolated 481 organisms from 378 peritoneal fluid specimens, coll
ected from 135 patients (45 children, 90 adults). There were 191 episodes o
f peritonitis in children (mean 4.2 +/- 3.5, range 1 - 15) compared to 187
in adults (2.1 +/- 1.9, range 1 - 10) (p < 0.001). Two or more episodes occ
urred in 30 of 45 children (67%) compared to 33 of 90 adults (37%) (p < 0.0
01). The number of different organisms/patient as well as the total number
of isolates/patient were significantly greater in children (respectively, 2
.8 +/- 2.3, range 1 - 12; and 5.3 +/- 5.2, range 1 - 27) than in adults (2.
0 +/- 1.3, range 1 - 6; and 2.7 +/- 2.4, range 1 - 10) (p < 0.005). After S
taphylococcus epidermidis, S. aureus was the most frequently isolated organ
ism, occurring in 18% of episodes in adults and 12% of episodes in children
(p< 0.01). Twenty-two of 33 fungal isolates (67%) in children were Candida
parapsilosis compared to 3 of 24 (12%) in adults (p < 0.001). Subanalysis
of multiple episodes revealed that Pseudomonas and Candida occurred signifi
cantly more often in children (p < 0.01), whereas S. aureus occurred more o
ften in adults (p < 0.001). in polymicrobial episodes S. epidermidis occurr
ed more often in adults (p < 0.05). Significant differences in susceptibili
ties to ampicillin, ceftriaxone, chloramphenicol, and gentamicin were found
between children and adults (p < 0.05 - 0.001).
Conclusions: CAPD-associated peritonitis occurs significantly more often in
children than adults. Significant differences in microbial etiology and su
sceptibilities were found between pediatric and adult patients. Each dialys
is unit should periodically analyze peritoneal fluid culture results from i
ts CAPD patients. These data can then be used for optimization of empirical
antimicrobial therapy of peritonitis.