Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)

Citation
Ai. Waechter et al., Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae), PHYTOTHER R, 13(2), 1999, pp. 175-177
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
13
Issue
2
Year of publication
1999
Pages
175 - 177
Database
ISI
SICI code
0951-418X(199903)13:2<175:AAOAAI>2.0.ZU;2-R
Abstract
On a preliminary screening, substantial leishmanicidal activity was observe d for the petroleum ether and alkaloidal extracts of the stem bark of Unono psis buchtienii, the alkaloids and sterols isolated from these were studied . Of the alkaloids, liriodenine exhibited the highest activity against Leis hmania major and L. donovani (IC100 = 3.12 mu g/mL). On the other hand, O-m ethylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against Trypanosoma brucei with an IC100 o f 6.25 mu g/mL. The highest cytotoxic activities were found with the petrol eum ether extracts without alkaloids and with all alkaloids isolated (IC50 < 9 mu g/mL for Vero cell line), Copyright (C) 1999 John Wiley & Sons, Ltd.