EFFECT OF PYRROLIDONE CARBOXYLATE (PCA) AND PYRIDOXINE ON LIVER-METABOLISM DURING CHRONIC ETHANOL INTAKE IN RATS

Authors
CALABRESE V RAGUSA N RIZZA V
Citation
V. Calabrese et al., EFFECT OF PYRROLIDONE CARBOXYLATE (PCA) AND PYRIDOXINE ON LIVER-METABOLISM DURING CHRONIC ETHANOL INTAKE IN RATS, International journal on tissue reactions, 17(1), 1995, pp. 15-20
Citations number
25
Categorie Soggetti
Cell Biology
Journal title
International journal on tissue reactions → ACNP
ISSN journal
02500868
Volume
17
Issue
1
Year of publication
1995
Pages
15 - 20
Database
ISI
SICI code
0250-0868(1995)17:1<15:EOPC(A>2.0.ZU;2-Z
Abstract
Rats subjected to chronic ethanol intake for a period of 28 days showe d significant elevation in blood ethanol levels, a marked decrease in hepatic reduced glutathione (GSH) content and a decrease in liver tryp tophan pyrrolase (TPO) activity. A daily intraperitoneal injection of a combined solution oi pyrrolidone carboxylate (PCA) and vitamin B-6 ( pyridoxine hydrochloride) (0.3 mmoles/kg) into ethanol treated rats re sulted in the blood ethanol levels becoming significantly reduced, whi le the hepatic GSH content and TPO activity were markedly elevated. Ou r results support the view that PCA and pyridoxine operate to restore the redox imbalance oi the hepatocytes caused by chronic alcohol intak e.