Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography mass spectrometry

Authors
Mester, Z Horvath, G Vitanyi, G Lelik, L Fodor, P
Citation
Z. Mester et al., Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography mass spectrometry, RAP C MASS, 13(5), 1999, pp. 350-353
Citations number
20
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
ISSN journal
09514198 → ACNP
Volume
13
Issue
5
Year of publication
1999
Pages
350 - 353
Database
ISI
SICI code
0951-4198(1999)13:5<350:SDODAA>2.0.ZU;2-F
Abstract
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic aci d (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm(-3) respectively. This simple and rapid method has good precision and ac curacy. Fragmentation routes of derivatized MMA and DMA are suggested on ac curate mass measurements. Copyright (C) 1999 John Wiley & Sons, Ltd.