Differentiation of acute renal failure and chronic renal failure by 2-dimensional analysis of urinary dipeptidase versus serum creatinine

The differential diagnosis of acute renal failure (ARF) and chronic renal f ailure (CRF) may be possible by measuring urinary dipeptidase (Udpase) acti vity and serum creatinine (S-Cr) concentration. When the mass test of 246 i ndividuals was examined on a 2-dimensional plot of Udpase (y-axis) versus S -Cr (x-axis) with the data obtained from healthy volunteers (n = 189), ARF (n = 19) and CRF (n = 38) patients, the characteristic distribution of each group was obvious. It is summarized by the mean values of healthy, volunte ers (1.44 +/- 0.39 mg/dL, 1.19 (0.59 mU/mL), ARF (6.04 +/- 5.04 mg/dL, 0.12 +/- 0.08 mU/mL), and CRF patients (8.72 +/- 2.93 mg/dL, 0.81 +/- 0.44 mU/m L). The healthy volunteers are distributed along the y-axis and the ARF pat ients the x-axis, thus separating the two groups 90 degrees apart The CRF p atients are scattered away from both x-, and y-axis. This 2-dimensional app roach is thought to be very useful for the differential diagnosis of ARF su ggesting Udpase as a new member of the marker enzymes of renal disease.