Enantioselective reduction of ketones. Examination of bifunctional ligands

Authors
Sibi, MP Cook, GR Liu, PR
Citation
Mp. Sibi et al., Enantioselective reduction of ketones. Examination of bifunctional ligands, TETRAHEDR L, 40(13), 1999, pp. 2477-2480
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2477 - 2480
Database
ISI
SICI code
0040-4039(19990326)40:13<2477:EROKEO>2.0.ZU;2-I
Abstract
New bifunctional ligands based on a cis-amino indanol framework have been e valuated in the reduction of prochiral ketones. These reductions proceed wi th high chemical efficiency and good-to-excellent enantioselectivity using borane and 10 mol% of an oxazaborolidine derived from cis-2-amino indanol l igand containing a 2-sulfonylpyridyl tether attached to the amino group. (C ) 1999 Elsevier Science Ltd. All rights reserved.